Shengkun Li PhD

Professor of Agrochemicals and Organic Chemistry

Doctoral Supervisor

State Key Laboratory of Green Pesticides

Contact details

Room 223, Building D, Center for R&D of Fine Chemicals, East Campus, Guizhou University

Email SKL505@outlook.com; SKLi@GZU.edu.cn

Phone ：+86 -13675143844

Qualifications

BSc – Pharmaceutical Engineering (Ranked 1st), Northwest A&F University, China 2007

MSc – Applied Chemistry (Ranked 1st), Northwest A&F University, China 2010

PhD – Chemical Biology, Northwest A&F University (China) and Rutgers University (USA), 2013

Positions held

2020/04—   Professor, Advisor for PhD candidates, State Key Laboratory of Green Pesticides, Guizhou University

2019/01—2020/04 Associate Professor, Advisor for PhD candidates, College of Plant Protection, Nanjing Agricultural University

2014/01—2018/12 Associate Professor, Advisor for Master candidates, College of Plant Protection, Nanjing Agricultural University

Profile

The research of Shengkun’s Lab (SKLab) is inspired by the coenzyme Q pathway in electron-transport chain and the related natural regulators, leading to  prominent pesticide innovations. Professor Li’s team has discovered β-heteroarylamines and drimane meroterpenoids for development of novel pesticides. They have also established the biomimetic design and XArOx and ArXOx models for founding of novel catalysts, facilitating precise construction and modular optimization of leads or drugs. Based on the aforementioned achievements, Shengkun has received numerous awards, including Yangtze River Scholar (young professor), High-level Talents of Nanjing, Hong Kong Scholarship, Excellent Doctoral Dissertation of Shaanxi Province, ACS Membership Award, etc.

For more details, please click the following links:

https://www.x-mol.com/groups/Shengkun

https://orcid.org/0000-0001-5458-0811

Selected publications (*corresponding authors)

1. Xiaodan He, Shengxin Sun, Wenlong Kong, Mengyang Li, Shengkun Li *, Eudistomins Y inspired design and divergent optimization of heteroaryl ketones for new antifungal leads, J. Agric. Food Chem. 2024, 72, 21, 11928–11937.

2. Shengxin Sun, Xiaodan He, Juan Yang, Xia Wang, Shengkun Li,*Facile synthesis and first antifungal exploration of tetracyclic meroterpenoids: (+)-aureol, (-)-pelorol and its analogs, J. Nat. Prod. 2024, 87 (4), 1092-1102.

3. Chen Yang, Shengxin Sun, Mengyang Li, Menglan Dou,Shengkun Li*, Design and discovery of α-oximido-arylacetamides as novel antifungal leads, J. Agric. Food Chem. 2024, 72, 12, 6702-6710.

4. Nvdan Hua, Xia Wang, Shengxin Sun, Juan Yang, Shengkun Li*, Practical synthesis and divergent optimization of halichonine b for the discovery of novel pharmaceutical leads, Org. Chem. Front. 2024, 11, 709-716.

5. Wenlong Kong, Nannan Li, Jixing Lai, Shengxin Sun, Shengkun Li*. Antifungal function oriented scaffold hopping for the discovery of oxazolyl-oxazoline as a novel model against Fusarium graminearum. J. Agric. Food Chem. 2023,71, 11, 18260-18269.

(6)Shengxin Sun, Xia Wang, René Csuk, and Shengkun Li,* Practical synthesis and antifungal investigation of drimane meroterpenoids enabled by nickel-catalyzed decarboxylative coupling, J. Nat. Prod. 2023, 86, 6, 1420-1427.

(7)Juan Yang, Jixing Lai, Wenlong Kong, Shengkun Li*,Asymmetric synthesis of sakuranetin-relevant flavanones for the identification of new chiral antifungal leads, J. Agric. Food Chem. 2022, 70, 11, 3409–3419.

(8)Jixing Lai, Chen Yang, René Csuk, Baoan Song, Shengkun Li *,Palladium catalyzed enantioselective hayashi-miyaura reaction for pharmaceutically important 4-aryl-3,4-dihydrocoumarins,Org. Lett. 2022, 24, 1329-1334.

(9)Jixing Lai, Juan Yang, Chen Yang, René Csuk, Baoan Song,Shengkun Li *, The first N-ligand assisted Pd catalyzed asymmetric synthesis of 3-arylsuccinimides as novel antifungal leads. Org. Chem. Front. 2022, 9, 183-189.

(10)Xia Wang, Nvdan Hu, Wenlong Kong, Baoan Song, Shengkun Li*, Facile and divergent optimization of chromazonarol enabled the identification of simplified drimane meroterpenoids as novel pharmaceutical leads. Eur. J. Med. Chem. 2022, 227, 113912.

Selected patents （Shengkun Li as the first inventor）

1, China Invention Patent number: ZL201910597142.3, authorized in 2022.

2, China Invention Patent number: ZL201910597141.9, authorized in 2022.

3, China Invention Patent number: ZL202210064775.X, authorized in 2023.

4, China Invention Patent number: ZL 202211085557.0, authorized in 2023.

5, China Invention Patent number: ZL 202210558617.X, authorized in 2023.

6, China Invention Patent number: ZL 202210552492.X, authorized in 2023.

7, China Invention Patent number: ZL 202210274285.2, authorized in 2023.

8, China Invention Patent number: ZL 202210947359.4, authorized in 2024.

9, China Invention Patent number: ZL 202210958730.7, authorized in 2024.

10, China Invention Patent number: ZL 202310070493.5, authorized in 2024.

ORCID iD: https://orcid.org/0000-0001-5458-0811