Director |
Bao-An Song PhD
Distinguished Professor of Pesticide Science and Pest Management
Academician of the Chinese Academy of Engineering (ACAE)
Doctoral Supervisor
State Key Laboratory of Green Pesticides
Contact details
Room 205, Building A, Centre for Research and Development of Fine Chemicals, Guizhou University, East Campus, Guizhou University, China
Phone +86 -851-88292184
Email basong@gzu.edu.cn
Qualifications
BSc - Guizhou University, Guiyang, Guizhou, China 1983
MSc - Shenyang Research Institute of Chemical Industry, China 1986
PhD - Nanjing Agricultural University, Nanjing, Jiangsu, China 2003
Selected positions held
2000-present Professor – Guizhou University, China
2004-present Director of the Key Laboratory of Green Pesticides and Agricultural
Bioengineering, Chinese Ministry of Education
2015 Elected as an Academician of the Chinese Academy of Engineering,
Government of China
2018-present Director of the State Key Laboratory of Green Pesticides, Government
of China
2018-present President of Guizhou University
Profile
Professor Song's research focuses on pesticide R&D and pest management. He has led over 30 projects, including the “973” Project and the Key Programs of National Natural Science Foundation of China. He has received the “Ho-Liang Ho-Li Foundation Award of Science and Technology” and the “Highest Scientific and Technological Contribution Award of Guizhou Province”. As the primary awardee, he has won three Second Prizes and one Third Prize of the “State Scientific and Technological Progress Award”, four First Prizes, and seven Second Prizes of provincial and ministerial science and technology progress awards. He has published over 350 scientific papers in internationally renowned journals such as Nature Biotechnology and Nature Plants and six monographs on pesticides with Springer and other publishers. He holds 36 national invention patents.
Professor Song has developed new production technologies for tolclofos-methyl, hymexazol, buprofezin, chlorpyrifos, and imidacloprid, which are widely used in industrial production and adopted by many pesticide companies in China, resulting in significant economic benefits. He has independently developed the bactericide, “Guangkuling”, which has become an important agent for controlling soil-borne diseases in China, contributing significantly to the advancement of the national pesticide industry. He also has created the highly effective antiviral agent “Dufulin” with independent intellectual property rights in China and proposed a new whole-process prevention and control method, solving major control problems of diseases like Southern rice black-streaked dwarf virus. Professor Song has proposed green pest control technology measures characterized by ecology as the root, agronomy as the foundation, and emergency control as auxiliary. He has led his team to carry out green control of major tea diseases and pests in major tea-growing counties in Guizhou Province, ensuring the quality and safety of tea products.
Song systematically expounded the concept of crop health-oriented immune regulation and green plant protection development, making significant contributions to innovation in green pesticides and development of plant protection in China. He has trained over 100 postdoctoral researchers and doctoral and master’s students. Under his leadership, the team has been awarded the National Advanced Group in Professional Technology and the National Innovative Talent Training Demonstration Base, helping Guizhou University's chemistry discipline rank in the top 1% globally according to ESI and establishing its plant protection discipline as a World-Class Construction Discipline.
Selected research grants (as PI):
1. National Key Research and Development Program of China (No. 2022YFD1700300)
2. National Key Research and Development Program of China (No. 2018YFD0200100)
3. Key Program of National Natural Science Foundation of China (No. 32330087)
4. Key Program of National Natural Science Foundation of China (No. 21732002)
5. Key Program of National Natural Science Foundation of China (No. 21132003)
6. General Program of National Natural Science Foundation of China (No. 21867002)
7. General Program of National Natural Science Foundation of China (No. 21732002)
8. General Program of National Natural Science Foundation of China (No. 21672044)
9. National Basic Research Program of China (973 Program)（No. 2010CB126105)
10. National Key Project for Basic Research Program of China (973 Program) (No. 2003CB114404)
Selected awards (as PI):
1. Second Prize of The State Scientific and Technological Progress Award (2019)
2. Second Prize of The State Scientific and Technological Progress Award (2014)
3. Second Prize of The State Scientific and Technologcial Progress Award (2007)
4. Third Prize of The State Scientific and Technological Progress Award (1998)
5. Second Prize of The National Teaching Achievement Award for Higher Education (Undergraduate) (2022)
6. The Ho-Liang Ho-Li Foundation Award of Science and Technology (2012)
7. First Prize of China Petroleum and Chemical Industry Federation Science and Technology Progress Award (2023)
8. First Prize of Science and Technology Progress Award, Chinese Higher Education Institution (2008)
9. First Prize of Guizhou Scientific and Technological Progress Award (2021)
10. First Prize of Guizhou Scientific and Technological Progress Award (2018)
Selected publications(*corresponding authors)
1. Song, R.; Zhang, Y.; Lu, P.; Wu, J.; Li, Q. X.; Song, B.* Status and Perspective on Green Pesticide Utilizations and Food Security. Annual Review of Food Science and Technology, 2024, 15. (10.1146/annurev-food-072023-034519).
This review gives a short explanation of what green pesticides are and discusses their importance, how they are currently registered and used in China, the EU, and the USA.
2. Zhang, A.; Zhang, H.; Wang, R.; He, H.; Song, B.*, Song, R.* Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants. Science China Life Sciences, 2024, 67(2): 391−402. (10.1007/s11427-023-2449-1).
This study identifies pyruvate kinase (PYK) as a potential new target against rice bacterial leaf blight and offers insights into the molecular and mechanistic aspects underlying anti-Xoo strategies that target PYK.
3. Lu, H.; Shen, Z.; Xu, Y.; Wu, L.; Hu, D.; Song, R.*; Song, B.* Immune Mechanism of Ethylicin-Induced Resistance to Xanthomonas oryzae pv. oryzae in Rice. Journal of Agricultural and Food Chemistry, 2023, 71(1), 288–299. (10.1021/acs.jafc.2c07385).
This research identifies OsCPK24 as a key mediator in rice resistance to Xoo, paving the way for the development of new bactericides leveraging OsCPK24. (Winner of the AGRO Division Research Article of the Year Award)
4. Yu, Q.; … Song, B.*; He, C.*; Jia, G*. RNA demethylation increases the yield and biomass of rice and potato plants in field trials. Nature Biotechnology, 2021, 39, 1581–1588. (s41587-021-00982-9).
This research demonstrates transgenic expression of the human RNA demethylase FTO in rice caused a significant increase in grain yield under both greenhouse conditions and field trials, indicating modulation of plant RNA m6A methylation is a promising strategy to dramatically improve plant growth and crop yield.
5. Lu, Y.; ... Song, B.*; Zhu, J. K.*; Li, H*.; Jiang, L*.; A donor-DNA-free CRISPR/Cas-based approach to gene knock-up in rice. Nature Plants, 2021, 7, 1445–1452. (s41477-021-01019-4).
This research shows that new genes and traits can be created in rice by designed large-scale genomic inversion or duplication using CRISPR/Cas9. CRISPR/Cas-based genome editing for gene knock-ups has been generally considered very difficult without inserting donor DNA as regulatory elements. This study challenges this notion by providing a donor-DNA-free strategy, thus greatly expanding the utility of CRISPR/Cas in plant and animal improvements.
6. Song, B.*; Seiber, J, N.; Duke, S. O.; Wu, L.; Li, Q. X. Green Plant Protection Innovation: Challenges and Perspectives. Engineering, 2020, 6(5), 483–484. (10.1016/j.eng.2020.04.001).
7. Li, Z.; Shi, J.; Hu, D.*; Song,B*. A polysaccharide found in Dendrobium nobile Lindl stimulates calcium signaling pathway and enhances tobacco defense against TMV. International Journal of Biological Macromolecules, 2019, 137, 1286–1297. (10.1016/j.ijbiomac.2019.06.179).
8. Ran, L.; Ding, Y.; Luo, L.; Gan, X.; Li, X.; Chen, Y.; Hu, D.*; Song, B*. Interaction research on an antiviral molecule that targets the coat protein of southern rice black-streaked dwarf virus. International Journal of Biological Macromolecules, 2017, 103, 919–930. (10.1016/ j.ijbiomac. 2017.05.059).
9. Zhang, W.; Li, X.; Zhang, G.; Ding, Y.; Ran, L.; Luo, L.; Wu, J.; Hu, D.*; Song, B.* Binding interactions between enantiomeric α-aminophosphonate derivatives and tobacco mosaic virus coat protein. International Journal of Biological Macromolecules, 2017, 94, 603–610. (10.1016/j.ijbiomac.2016.10.027).
10. Yang, X.; Song, B.*; Jin, L.; Wei, X.; Bhadury, S. P.; Li, X.; Yang, S.; Hu, D. Synthesis and antiviral bioactivities of novel chiral bis-thiourea-type derivatives containing α-aminophosphonate moiety. Science China-Chemistry, 2011, 54(1): 103–109. (10.1007/s11426-010-4179-5).
Selected patents
1. Song, B. A.; Pang, Y. X. The synthesis method of hymexazol, China Invention Patent number: ZL 99115140.2, 2002.
2. Song, B. A.; Song, Z. L.; Hu, D. Y. A group of agricultural pesticides and its preparation method with cyfluthrin as raw materials, China Invention Patent number: ZL 00132045.9, 2005.
3. Song, B. A.; Wu, Y. L.; Huang, R. M. The synthesis of fluoride α-amino alkyl phosphonic acid ester with the activity of anti-plant virus, China Invention Patent number: ZL02113252.6, 2006.
4. Song, B. A.; Zhang, G. P.; Hu, D. Y.; Pang, L. L.; Yang, S.; Liu, G.; Wang, H. The synthesis method and use of N- substituted benzothiazolyl -1- substituted phenyl -O, O- two -α- alkyl amino phosphonate ester derivative, China Invention Patent number: ZL 200510003041.7, 2006.
5. Song, B. A.; Li, W. H.; Yang, S.; Hu, D. Y.; Jin, L. H.; Wei, X.; Fan, H. T.; Xue, W.; Li, L. The synthesis method and use of a kind of optical activity of β-amino acid ester with benzothiazole moieties, China Invention Patent number: ZL201010159758.1, 2011.
6. Song, B. A.; Gou, X. T.; Hu, D. Y.; Cai, X. J.; Chen, H. J.; Yang, S.; Xue, W. The synthesis method and use of a kind of phenyl cyanoacrylate derivatives with amino phosphonate, China Invention Patent number: ZL200910102548.6, 2011.
7. Song, B. A.; Hu, D. Y.; Li, S. B.; Yang, S.; Jin, L. H.; Huang, Y. J. The synthesis method and use of 1, 5- two heterocyclic base - 1, 4-pentadiene-3-ketone derivatives, China Invention Patent number: ZL200910102435.6, 2011.
8. Song, B. A.; Wu, J.; Xue, W.; Chen, P. L.; Yang, S.; Zeng, S.; Hu, D. Y.; Wang, Z. C.; Xu, W. M. The synthesis method and insecticidal activity use of 1, 5-2 replaced aryl-1, 4- pentadiene -3-ketone oxime ethers compounds, ZL201010272708.4, 2012.
9. Song, B. A.; Yang, S. J.; Xue, W.; Jin, L. H.; Yang, S.; Hu, D. Y.; Li, X. Y.; Chen, Z. A preparation method of drug to anti-plant viruses, China Invention Patent number: ZL200810069089.1, 2013.
10. Xue, W.; Bai, S.; Xie, H. P.; Chen, Z.; Song, B. A.; Yang, S.; Hu, D. Y.; Jin, L. H. A preparation method and usage of Pesticide compounds mixed with pymetrozine and thiamethoxam, China Invention Patent number: ZL200910102604.6, 2012.
ORCID iD: 0000-0002-4237-6167