Shi-Chao Ren PhD

Shi-Chao RenProf., Dr.

Professor of Pesticide

Doctoral Supervisor

State Key Laboratory of Green Pesticide

Contact details

Guizhou University

Room: SKLGP-D 202

Email: scren@gzu.edu.cn

Phone number: +86 18326692093

Qualifications

Bachelor – Weifang University, China 2013

PhD – University of Science and Technology of China, China 2018

Positions held

2018-2019 Senior Organic Synthetic Chemist, Pharmaron, China

2019-2023 Postdoc – Nanyang Technological University, Singapore

2024 – present Professor – Guizhou University, China

Profile

Prof. Dr. Shi-Chao Ren completed his PhD at the University of Science and Technology of China in 2018 under the supervision of Prof. Yi-Feng Wang, where he focused on the development of new reactivities of boryl radicals to synthesize organoboron compounds. In 2019, he joined the Prof. Robin Chi group at the Nanyang Technological University for postdoctoral studies into NHC catalysis. He then began his independent career at Guizhou University in 2023. His works have been published in journals such as Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., J. Agric. Food Chem., ACS Catal. His current research interest includes the development of novel catalytic synthetic methodologies, designing bioactive molecules, and investigating their agricultural bioactivities.

Selected recent publications

1.T. Liao, X. Zhao, F. Yang, G. Xu, D. Chen, T. Tu, S. Huang, S.-C. Ren, Y. R. Chi, Carbene-Catalyzed Nitrogen to Carbon Aryl Migration via a Radical-Neutral Crossover Process, ACS Catal. 2025, Just accepted.

2.H. Cai, X. Zhang, D. Ling, M. Zhang, C. Pang, S.-C. Ren, Z. Jin, Y. R. Chi, Discovery of novel benzoxazinone derivatives as promising protoporphyrinogen IX oxidase inhibitors, Pest Manag Sci2025, 81, 4913-4921.(05-09)

3.C. Pang, M. Zhang, H. Cai, C. Song, Z. Jin, S.-C. Ren,* Y. R. Chi* Design, Synthesis, and Herbicidal Activity of Biaryl-Pyridazinone/Phthalimide Derivatives as Novel Protoporphyrinogen Oxidase Inhibitors, J. Agric. Food Chem. 2025, 73, 6458-6467.

4.T. Zhang, L. Wang, T. Tu, L. Liao, D. Chen, X. Peng, D. Liu, Z. Cheng, S. Huang, S.-C. Ren,* X. Zhang,* Y. R. Chi* NHC-Mediated Photocatalytic Para-Selective C-H Acylation of Aryl Alcohols: Regioselectivity Control via Remote Radical Spiro Cyclization, Sci. China Chem.2025, 68, 3611–3621.

5.Jin, J., Ren, S.-C.* Chi Y. R.* Chiral boryl radical catalyzed asymmetric radical cycloisomerization, Sci. China Chem. 2024, 67, 2121-2123.

6.Cai, H., Yang, X., Ren, S.-C., Chi, Y. R.*, Radical Reactions with N Heterocyclic Carbene (NHC)-Derived Acyl Azoliums for Access to Multifunctionalized Ketones, ACS. Catal. 2024, 14, 8270-8293.

7.Cai, H., Zhang, X., Ling D., Zhang, M., Pang, C., Chen, Z., Jin, Z., Ren, S.-C.*; Chi, Y. R.*, Discovery of pyridyl-benzothiazol hybrids as novel protoporphyrinogen oxidase inhibitors via scaffold hopping, J. Agric. Food Chem. 2024, 72, 8963-8972.

8.Nie, G., Tu, T., Liao, T., Liu, D., Ye, W., Ren, S.-C.*, N-heterocyclic carbene and photocatalyst-catalyzed rapid access to indole ketones via radical C(sp3)–H acylation, Green Chem., 2024, 26, 5397-5408.

9.Peng, X., Huang, Y., Wang, W., Li, S., Hao, G.-F., Ren, S.-C.*; Chi, Y. R. *, N Heterocyclic Carbene-Catalyzed Remote Enantioselective C−C Bond Formation via 1,6-Additionwith Formyl Enynes, ACS. Catal.2024, 14, 2127-2133.

10.Chen, Z., Cai, H., Zhang, X., Zhang, M., Hao, G.-F., Jin, Z., Ren, S.-C.*; Chi, Y. R.*, Design, Synthesis, and Herbicidal Activity of Substituted 3 (Pyridin-2-yl)Phenylamino Derivatives, J. Agric. Food Chem. 2024, 72, 2501-2511.

11.Ye, X.-Y., Wang, G., Jin, Z., Ren, S.-C.*; Chi, Y. R.*, Direct Forging Amide-Linked C-Glycosyl Amino Acids and Peptides via Ni-Catalyzed Photoredox Cross-Coupling Reactions, J. Am. Chem. Soc.2024, 146, 5502-5510.

12.Song, R.; Ren, S.-C.*; Chi, Y. R.*, Carbene- and photocatalysis redefine arene acylation, Nat. Synth. 2023, 2, 1009.

13.Ji, H.; Mou, C.; Zou, J.; Liu, Y.; Ren, S.-C.*; Chi, Y. R.* NHC-catalyzed [12 + 2] reaction of polycyclic arylaldehydes for access to indole derivatives, Chem. Commun. 2023, 59, 6351-6354.

14.Bao, Z.; Zou, J.; Mou, C.; Jin, Z.; Ren, S.-C.*; Chi, Y. R.* Direct Reaction of Nitroarenes and Thiols via Photodriven Oxygen Atom Transfer for Access to Sulfonamides, Org. Lett. 2022, 24, 8907.

15.Ren, S.-C.;Yang, X.;Mondal, B.; Mou, C.; Tian, W.*; Jin, Z.; Chi, Y. R.* Carbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketones, Nat. Commun.,2022, 13, 2846.

16.Ren, S.-C.;Lv, W.-X.; Yang, X.; Yan, J.-L.; Xu, J.; Wang, F-X.; Hao, L.; Chai, H. *; Jin, Z.; Chi, Y. R.* Carbene-Catalyzed Alkylation of Carboxylic Esters via Direct Photoexcitation of Acyl Azolium Intermediates, ACS. Catal.2021, 11, 2925-2934.

17.Ren, S.-C.^‡; Zhang, F.-L.^‡; Xu, A.-Q.; Yang, Y.; Zheng, M.; Zhou, X.*; Fu, Y.*; Wang, Y.-F.* Regioselective radical α-borylation of α,β-unsaturated carbonyl compounds for direct synthesis of α-borylcarbonyl molecules, Nat. Commun. 2019,10, 1934.

18.Ren, S.-C.^‡;Zhang, F.-L.^‡; Qi, J.; Huang, Y.-S.; Xu, A.-Q.; Yan, H.-Y.; Wang, Y.-F.* Radical Borylation/Cyclization Cascade of 1,6-Enynes for the Synthesis of Boron-Handled Hetero- and Carbocycles, J. Am. Chem. Soc. 2017, 139, 6050-6053.

19.Ren, S.-C.^‡; Song, S.^‡; Ye, L.; Feng, C.*; Loh, T.-P.* Copper-catalyzed oxyamination of electron-deficient alkenes with N-acyloxyamines, Chem. Commun.2016, 52, 10373-10376.Ren, S.-C.; Feng, C.*; Loh, T.-P.* Iron- or Silver-Catalyzed Oxidative Fluorination of Cyclopropanols for the Synthesis of β-Fluoroketones, Org. Biomol. Chem.2015, 13, 5105-5109.

20.Yang, X.^‡; Xie, Y.^‡; Xu, J.; Ren, S.-C.; Mondal, B.; Zhou, L.;Tian, W.*; Zhang, X.*; Hao, L.; Jin, Z.; Chi, Y. R.* Carbene-Catalyzed Activation of Remote Nitrogen Atoms of (Benz)imidazole-Derived Aldimines for Enantioselective Synthesis of Heterocycles, Angew. Chem. Int. Ed.2021, 133, 7985-7991.

21.Yan, J.-L.^‡; Maiti, R.^‡; Ren, S.-C.; Tian, W.*; Li, T.; Xu, J.; Mondal, B.; Jin, Z.; Chi, Y. R.* Carbene-Catalyzed Atroposelective Synthesis of Axially Chiral Styrenes, Nat. Commun.2022, 13, 84.

22.Wang, F.-X.; Yan, J.-L.; Liu, Z.; Zhu, T.; Liu, Y.; Ren, S.-C.; Lv, W.-X.; Jin. Z.; Chi, Y. R. * Assembly of multicyclic isoquinoline scaffolds from pyridines: formal total synthesis of fredericamycin A. Chem. Sci.2021, 12, 10259-10265.

23.Qing, J.^‡; Zhang, F.-L.^‡; Huang, Y.-S.; Xu, A.-Q; Ren, S.-C.; Yi, Z.-Y.; Wang, Y.-F.* Radical Borylative Cyclization of 1,6-Dienes: Synthesis of Boron-Substituted Six-Membered Heterocycles and Carbocycles, Org. Lett.2018, 20, 2360-2364.