Run-Jiang Song PhD

Professor of Green Pesticides

Doctoral Supervisor

State Key Laboratory of Green Pesticides 

Contact details

Room 205 in Building A, Center for Research and Development of Fine Chemicals, East Campus, Guizhou University

Email songrj@gzu.edu.cn

Phone (+86) 18818279760

Qualifications

PhD - Nanyang Technological University, Singapore 2021

BSc - East China University of Science and Technology, Shanghai, China 2016

Profile

Runjiang’s research focuses on the development of green pesticides, including the design of new agrochemical structures derived from natural products, bioactivity screening, and the application of advanced molecular biology techniques to elucidate their mechanisms of action. He has identified pyruvate kinase as a potential new target against rice bacterial leaf blight and uncovered rice calcium-dependent protein kinase 24 as a target for inducing plant resistance to bacterial diseases.

Research funding:

1. General Program of National Natural Science Foundation of China (No. 32272590)

2. Youth Fund of the National Natural Science Foundation of China (No. 32302388)

Awards:

1. Journal of Agricultural and Food Chemistry Research Article of the Year Award (2024)

2. First Prize of Science and Technology Progress Award of Guizhou (2023)

Selected Recent Publications (*corresponding authors)

1. Song, R.*; Zhang, Y.; Lu, P.; Wu, J.; Li, Q. X.; Song, B. Status and Perspective on Green Pesticide Utilizations and Food Security. Annual Review of Food Science and Technology, 2024, 15. (10.1146/annurev-food-072023-034519).

This review gives a short explanation of what green pesticides are and discusses their importance, how they are currently registered and used in China, the EU, and the US. Following this, we do a thorough study of how the newest green pesticides affect communities and the environment. Finally, we look at the possible dangers of eating foods that contain green poisons, as well as the risks of long-term toxicity and cancer.

2. Wei, C.; Zhao, C.; Li, J.; Li, C.; Song, B.; Song, R.* Innovative Arylimidazole-Fused Phytovirucides via Carbene-Catalyzed [3+4] Cycloaddition: Locking Viral Cell-To-Cell Movement by Out-Competing Virus Capsid-Host Interactions. Advanced Science, 2024, 2309343. (10.1002/advs.202309343).

A highly efficient and selective carbene-catalyzed [3+4] cycloaddition is developed in this study, which allows the one-step synthesis of a series of optically-enriched imidazo[1,2-α][1,4]diazepins. Compound -3j (S) is screened out as a potential phytovirucide that locks cell-to-cell movement of potato virus Y by out-competing virus capsid-host interactions at the molecular level.

3. Zhang, A.; Zhang, H.; Wang, R.; He, H.; Song, B., Song, R.* Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants. Science China Life Sciences, 2024, 67(2): 391−402. (10.1007/s11427-023-2449-1).

This study identifies pyruvate kinase as a potential new target against rice bacterial leaf blight and offers insights into the molecular and mechanistic aspects underlying anti-Xoo strategies that target PYK.

4. Song, R.*; Ren, S.; Chi, Y. R. Carbene-and photocatalysis redefine arene acylation. Nature Synthesis, 2023, 2(11): 1009−1011. (10.1038/s44160-023-00400-9).

5. Lu, H.; Shen, Z.; Xu, Y.; Wu, L.; Hu, D.; Song, R.*; Song, B.* Immune Mechanism of Ethylicin-Induced Resistance to Xanthomonas oryzae pv. oryzae in Rice. Journal of Agricultural and Food Chemistry, 2023, 71(1), 288–299. (10.1021/acs.jafc.2c07385).

This research identifies OsCPK24 as a key mediator in rice resistance to Xoo, paving the way for the development of new bactericides leveraging OsCPK24. (Winner of the AGRO Division Research Article of the Year Award)

6. Song, R.; Xie, Y.; Jin, Z.; Chi, Y. R.* Carbene-Catalyzed Asymmetric Construction of Atropisomers. Angewandte Chemie-International Edition, 2021, 60(50), 26026–26037;

ORCID iD: 0000-0003-2502-778X