Xing-Xing Wu PhD

Xingxing WuPhD

Professor of Pesticide Chemistry

Doctoral Supervisor

State Key Laboratory of Green Pesticides (link to the main page of the lab)

https://orcid.org/0000-0002-6281-243X

Contact details

Office 336, Building D, East Campus, Guizhou University

Email wuxx@gzu.edu.cn

Phone 13673292839

Qualifications

2013.08-2017.11  Nanyang Technological University (Singapore), PhD (Advisor: Prof. Yonggui Robin Chi)

2010.09-2013.06  East China Normal University, MSc (Advisor: Prof. Junliang Zhang)

2006.09-2010.06  East China Normal University,  BSc (Advisor: Prof. Junliang Zhang)

Positions held

2022.05-present   Professor, Guizhou University, China

2018.05-2022.02  Marie Skłodowska-Curie Postdoctoral Research Fellow, University of Basel, Switzerland

2018.02-2018.05  Project Officer, Nanyang Technological University, Singapore

Profile

Xingxing has been selected for the National Overseas High-Level Young Talents Program. He serves as the academic discipline leader at Guizhou University, and a youth editorial board member of the Journal of Pesticide Science. He was appointed as a Marie Curie scholar by the European Research Council. His research focuses on the development of green and efficient asymmetric catalytic synthesis methods. He has established a series of universal asymmetric preparation technology models, facilitating the efficient construction of various libraries of chiral compounds with pesticide activity. As the first author or corresponding author, he has published over 30 papers in high-impact journals such as Nature Catalysis, Chem, Angewandte Chemie International Edition, and Trends in Chemistry. Some of his achievements have been recognized with awards such as the 2023 Qingyuan Green Pesticide Outstanding Teacher Award, the Swiss Chemical Society-Helvetica 2^nd Prize (2023), RSC Chem. Commun. Emerging Investigators (2025) and Org. Chem. Front. Emerging Investigators (2025) and the 2017 China Scholarship Council's "Outstanding Self-Financed Overseas Student Scholarship."

Selected recent publications (*corresponding authors)

 Wang, Y. Chen, K. Che, F. Zhao, S. Feng, P. Zhao, Q. Wei D*Wu, X.* and Y. R. Chi* (2025). NHC-catalyzed covalent activation and control of P (V)-stereogenic phosphorus centers via phosphonyl azolium intermediates. Chem. DOI: 10.1016/j.chempr.2025.102586.

 Xiong, Q. Liao, M. Zhao, S. Wu, S. Hong, Y. R. Chiand Wu, X.* (2025). Asymmetric Synthesis of S (IV)‐Stereogenic Sulfinimidate Esters by Sulfinamide Activation. Angew. Chem. Int. Ed. 64, e202500170.

 Liao, M. Huang, S. Xiong, Q. Luo, Z. Zhao, S. Xu, T. Wu, X.* (2025). Asymmetric catalytic reductive transformation of S (VI) to S (IV) for modular access to S (IV)-stereogenic sulfilimine derivatives. Science Advances, 11, eadx2509.

 Li, B. Hu, J. Xu, Z. Liao, M. Y. R. Chi and Wu, X.* (2025). Control Over S (VI) Stereogenicity for the Asymmetric Synthesis of Sulfonimidoyl Derivatives by Isothiourea‐Catalyzed Covalent Activation of Sulfur (VI) Atoms. Angew. Chem. Int. Ed., e202510595.

 Jian, C. Huang, X. Long, H. Liao, M. Wu, X.* (2025). Heteroarylation of Sulfenamides for Modular Synthesis of Antimicrobial Sulfilimines via Sulfinimidoyl Fluoride Intermediates. Org. Lett., 27(21), 5464-5470.

 Hu, Y. Hong, Y. Zheng, Y. Huang, Y. Chen, J. Wu, X.* (2025). Synthesis of antimicrobial active 9, 10-phenanthrenequinones by carbene organocatalytic tandem reactions. Org. Chem. Front., 12(6), 1778-1785.

 Long, Y. Feng, P. Long, H. Huang, Y. Wu, X.* (2025). Stable sulfonate esters as C1-synthons for cyclopropanation reaction to access antimicrobial active 3, 3′-spirocyclopropyloxindoles. Org. Chem. Front., 12(13), 3863-3869.

 Zhao, S. Wu, X. Xu, Z. Ye, S. Wu, X.* (2025). Metal‐Free Alkane Functionalization by Organocatalytic and Photoinduced Methods. Chem. Record., e202400265.

 Xiong, Q. Liao, M. Wang, G. Shi, H. and Wu, X.*. (2025). Synthesis of chiral N-free sulfinamides by asymmetric condensation of stable sulfinates and ammonium salts. Chem. Commun., 61(14), 3017-3020.

Zhao, Y. Ji, X. Xiao, Y. Wu, X.*, Liu, L. (2025). Copper-catalyzed chemoselective C–H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds. Chem. Commun., 61(27), 5162-5165.

Wu, X. Zhao, Q. Zheng, Y. Long, Y. Wu, X.* (2025). Assembly of Molecular Complexity by Carbene Organocatalytic Multicomponent Reactions Involving α, β‐Unsaturated Aldehydes. Eur. J. Org. Chem., 28(23), e202500220.

 Che, F. Hu, J. Liao, M. Luo, Z. Long, H. Li, B. Y. R. ChiandWu, X.*. (2024). Synthesis of P()-stereogenic phosphorus compounds via organocatalytic asymmetric condensation. J. Am. Chem. Soc (49), 146.

 Li, B, Hu, J, Liao, M. Xiong, Q. Zhang, Y., Chi, Y. R. Chi, ZhangX*,Wu, X.*. (2024). Catalyst control over S (IV)-stereogenicity via carbene-derived sulfinyl azolium intermediates. J. Am. Chem. Soc, 146(36), 25350-25360.

Luo, Z, M. Liao, W. Li, S. Zhao, K. Tang, P. Zheng, Y. R. Chi, X. Zhang* and Wu, X.* (2024). Ionic Hydrogen Bond-Assisted Catalytic Construction of Nitrogen Stereogenic Center via Formal Desymmetrization of Remote Diols. Angew. Chem. Int. Ed. 63: e202404979.

 Liao, M., Y. Liu, H. Long, X. Lv,Z. Luo, F. Che, Wu, X.* and Y. R. Chi* (2024)Enantioselective sulfinylation of alcohols and amines by condensation with sulfinates. Chem. doi: 10.1016/j.chempr.2024.02.016.

Lv, X.,F. Su, H. Long, F. Lu,Y. Zeng, M. Liao, F. Che, Wu, X.* and Y. R. Chi* (2024) Carbene Organic Catalytic Planar Enantioselective Macrolactonization. Nat. Commun. 15: 958.

Su, F., F. Lu, K. Tang, X. Lv, Z. Luo, F. Che, H. Long, Wu, X.* and Y. R. Chi*(2023) Organocatalytic C-H Functionalization of Simple Alkanes. Angew. Chem. Int. Ed. 62: e202310072.

Su, F., J. Zou, X. Lv, F. Lu, Y. Long, K. Tang, B. Li, H. Chai, Wu, X.* and Y. R. Chi*(2023)Carbene-Catalyzed Intermolecular Dehydrogenative Coupling of Aldehydes with C(sp³)-H Bonds. Angew. Chem. Int. Ed.62: e202303388.

Long, H., S. Zhao, C. Jian, X. Wu, F. Lu, M. Liao, F. Che, Wu, X.* and Y. R. Chi* (2024)Carbene-catalyzed Enantioselective Seleno-Michael Addition as Access to Antimicrobial Active Se-containing Heterocycles. Sci. China. Chem. doi: 10.1007/s11426-023-1909-5.

Shen, T. Jin, J. Song, J., Naz, H., Jin, Z., Y. R. Chiand Wu, X.* (2024). Design, enantioselective synthesis, and antiviral activities against potato virus Y of axially chiral thiazine derivatives. Journal of Heterocyclic Chemistry, 61(3), 421-429.

Lu, F. Su, F. Pan, S. Wu, Wu, X.* and Y. R. Chi (2024). N‐Heterocyclic Carbene Enabled Functionalization of Inert C (sp³)−H Bonds via Hydrogen Atom Transfer (HAT) Processes. Chemistry–A European Journal, 30(47), e202401811.

Yang, X. Jiang, S. Zhang, M. Li, T. Jin, Z, Wu, X.* and Y. R. Chi. (2024). Discovery of novel piperidine‐containing thymol derivatives as potent antifungal agents for crop protection. Pest Management Science, 80(10), 4906-4914.

 Long, H. Zhao, S. Jian, C. Wu, X. Lu, F. Liao, M. Che, F. Wu, X.*and Chi, Y. R. (2024). Carbene-catalyzed enantioselective seleno-Michael addition as access to antimicrobial active Se-containing heterocycles. Science China Chemistry, 67(7), 2199-2205.

Wu, X.,R. Witzig,R. Beaud, C. Fischer, D. Häussinger, C. Sparr* (2021) Catalyst Control over Sixfold Stereogenicity. Nature Catal 4: 457−462.

Wang, H., Wu, X.* and Y. R. Chi*(2022) Distal Difunctionalization of Aldehydes via the Triplet State of Breslow Intermediates. Chem Catal. 2: 3275–3277.

Tang, K., F. Su, S. Pan, F. Lu, Z. Luo, F. Che,Wu, X.* and Y. R. Chi*(2024) Enones from Aldehydes and Alkenes by Carbene-catalyzed Dehydrogenated Couplings. Chin. Chem. Lett.doi: 10.1016/j.cclet.2024.109495.

Teng, K., Q. Liu, M. Zhang, H. Naz, Wu, X.* and Y. R. Chi*(2024) Design, Enantioselective Synthesis of Chiral Pyranone Fused Indole Derivatives with Antibacterial Activities against Xanthomonas oryzae pv. oryzae for Protection of Rice. J. Agric. Food. Chem.72: 4622–4629.

Wang, Y., Y. Liu, S. Zhao, Y. Long, Wu, X.*(2023) Catalyst-controlled Stereoselective Carbon‒heteroatom Bond Formations by N-Heterocyclic Carbene (NHC) Organocatalysis. Org. Chem. Front.10: 4437–4458.

Wang, H., F. Su, Y. Wang, Wu, X.* and Y. R. Chi*(2023) Direct coupling of inert C–H bonds in NHC organocatalysis. Org. Chem. Front. 10: 5291–5295.

Liu, Y., Y. Wang, Wu, X.* and Y. R. Chi*(2022) Exploring Molecular Complexity by N-Heterocyclic Carbene Organocatalysis: New Activation and Reaction Diversity. Chem. Record 22: e202200219.

Wu, X., Liu, Y., Jin, Z. Organocatalytic Dynamic Kinetic Resolution (Chapter 3) in Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT) (Eds. J.-E. Bäckvall), 2022, Georg Thieme Verlag KG, Stuttgart, Germany. (Book chapter)

Wu, X., C. Sparr* (2022) Retrosynthetic polyketide disconnections for unnatural aromatics, Trends in Chem.4: 367−370.

Wu, X., C. Sparr* (2022) Stereoselective Synthesis of Atropisomeric Acridinium Salts by the Catalyst-Controlled Cyclization of ortho-Quinone Methide Iminiums. Angew. Chem. Int. Ed.61: e202201424.

Wu, X, L. Zhou,R. Maiti, C. Mou, L. Pan* and Y. R. Chi* (2019) Sulfinate and Carbene Co-catalyzed Rauhut-Currier Reaction for Enantioselective Access to Azepino[1,2-a]indoles. Angew. Chem. Int. Ed. 58: 477−481.

Wu, X., L. Hao, Y. Zhang, M. Rakesh, R. N. Reddi, S. Yang,* B. Song and Y. R. Chi* (2017) Construction of Fused Pyrrolidines and β-Lactones by Carbene-Catalyzed C−N, C−C, and C−O Bond Formations. Angew. Chem. Int. Ed.56: 4201−4205.

Wu, X., Y. Zhang, Y. Wang, J. Ke, M. Jeret, R. N. Reddi, S. Yang, B. Song* and Y. R. Chi* (2017) Polyhalides as Efficient and Mild Oxidants for Oxidative Carbene Organocatalysis by Radical Processes. Angew. Chem. Int. Ed.56: 2942−2946.

Wu, X., B. Liu,Y. Zhang, M. Jeret, H. Wang, P. Zheng, S. Yang, B. Song and Y. R. Chi* (2016) Enantioselective Nucleophilic β-Carbon-Atom Amination of Enals: Carbene-Catalyzed Formal [3+2] Reactions. Angew. Chem. Int. Ed.55: 12280−12284.

Zhou, L.J.,Wu, X.,X. Yang, C. Mou, R. Song, S. Yu, H.  Chai, L.  Pan, Z. Jin and Y. R. Chi* (2020) Gold and Carbene Relay Catalytic Enantioselective Cycloisomerization/Cyclization Reactions of Ynamides and Enals. Angew. Chem. Int. Ed. 59: 1557−1561.