Wen-Chao Yang

Distinguished Professor of Pesticide Chemical Biology

Doctoral Supervisor

State Key Laboratory of Green Pesticides 

Contact details

Room 503, Center for Research and Development of Fine Chemicals, East Campus, Guizhou University

Email: wcyang@gzu.edu.cn

Phone 18171425138/0851-83636718

Qualifications

BSc – Central China Normal University, China 2003

PhD – Central China Normal University, China 2009

PhD – Joint PhD in University of Kentucky, USA 2009

Positions held

2009 – 2012 Lecturer – Central China Normal University, China

2010 – 2011 Postdoc – University of Kentucky, USA

2014 – 2015 Postdoc – The Hong Kong Polytechnic University, China

2012 – 2017 Associate Professor – Central China Normal University, China

2017 – 2022 Professor – Central China Normal University, China

2023 – present Professor – Guizhou University, China

Profile

Wen Chao Yang is an enzyme chemist. His research focuses on the enzyme-targeted chemical biology studies for pesticide discovery and plant protection. He has served as member of several esteemed organizations, including the Chinese Chemical Society, the American Pharmaceutical Association, and the Youth Editorial Committee of the Journal of Analysis and Testing. He has authored over 60 articles in peer reviewed journals, such as J. Am. Chem. Soc., ACS Nano, ACS Sensors, Anal. Chem. and The FEBS J, J. Agric. Food Chem., Eur. J. Med. Chem. and Chem. Commun. He has got about 10 Chinese and US patents approved so far. He was selected for the Cheung Kong Scholars Programme in 2023.

Selected recent publications (*corresponding authors)

Ju, W.L., J.Liu, W.C. Yang*, Q.H. Fan, M.Huang, and L.C. Fang* (2024) Enhancing soil ecological security through phytomanagement of tailings in erosion-prone areas. J. Hazard. Mater. 462: 132730.

Yang, W.C.*, S.Y. Li, S.N. Ni, and G.Z. Liu* (2023) Advances in FRET-based biosensors from donor-acceptor designto applications. Aggregate DOI:10.1002/agt2.460.

Wu, H., J.H. Li, W.C. Yang, T. Wen, J. He, Y.Y. Gao*, G.F. Hao*, and W.C. Yang* (2023) Nonmetal-doped quantum dot-based fluorescence sensing facilitates the monitoring of environmental contaminants. Trends Environ. Anal. Chem. 40: e00218.

Ndikuryayo, F., and W.C. Yang* (2023) New insights into the interactions between herbicides: trends from recent studies. J. Agric. Food Chem. 71: 10970−10981.

Guo, W.Y., Y.X. Fu, L.C. Mei, Z. Chen, Z.Y. Zhang, F. Wang, W.C. Yang*, G.Z. Liu*, and G.F. Yang* (2023) Rational design of esterase-insensitive fluorogenic probes for in vivo imaging. ACS Sens. 8: 2041−2049.

Lin, Z.B., Y.X. Zhao, and W.C. Yang* (2023) A balanced mechanism between plant growth and stress response. Adv. Agrochem. 2:105–106.

Fu, Y.X., W.Y. Guo, N. Wang, Y.J. Dai, Z.Y. Zhang, X.L. Sun, W.C. Yang*, and G.F. Yang (2022) Diagnosis of bacterial plant diseases via a nitroreductase-activated fluorescent sensor. Anal. Chem. 94:17692−17699.

Fu, Y.X., Z.Y. Zhang, W.Y. Guo, Y.J. Dai, Z.Y. Wang, W.C. Yang*, and G.F. Yang* (2022) In vivo fluorescent screening for HPPD-targeted herbicide discovery. Pest Manag. Sci. 78: 4947–4955. (Front cover)

Fu, Y.X., S.Y. Liu, W.Y. Guo, G.Z. Liu, J. Dong, J.X. Nan, H.Y. Lin, L.C. Mei, W.C. Yang*, and G.F. Yang* (2022) In vivo diagnostics of abiotic plant stress responses via in situ real-time fluorescence imaging. Plant Physiology, 190: 196−201.

Guo, W.Y., R.R. Li, S.Y. Liu, Y.X. Fu, G.Z. Liu, W.C. Yang*, and G.F. Yang (2021) Pyroglutamate aminopeptidase I promotes hepatocellular carcinoma via IL-6/STAT3 activation as revealed by a specific biosensor. Anal. Chem. 93: 13311−13318.

Lin, H.Y., X.Chen, J. Dong, Y. Ye, H. Xiao, C.G. Zhan, W.C. Yang*, and G.F. Yang* (2021) Rational redesign of enzyme via the combination of quantum mechanics/molecular mechanics, molecular dynamics, and structural biology study. J. Am. Chem. Soc., 143: 15674−15687.

Wang, XN, Lin, HY, Liu, JJ, Zhao, XY, Chen, X* , Yang, WC*, Yang, GF*, Zhan, CG (2021) The structure of 4-hydroxylphenylpyruvate dioxygenase complexed with 4-hydroxylphenylpyruvic acid reveals an unexpected inhibition mechanism, Chin. Chem. Lett. 32: 1920−1924.

Rajapaksha, A.A., Y.X. Fu, W.Y. Guo, S.Y. Liu, Z.W. Li, C.Q. Xiong, W.C. Yang*, and G.F. Yang (2021) Review on the recent progress in the development of fluorescent probes targeting enzymes. Methods and Applications in Fluorescence 9: 032001.

Guo, W.Y., Y.X. Fu, S.Y. Liu, L.C. Mei, Y. Sun, J. Yin, W.C. Yang*, and G.F. Yang* (2021) Multienzyme-targeted fluorescent probe as a biosensing platform for broad detection of pesticide residues. Anal. Chem. 93: 7079−7085.

Qu, R.Y., J.F. Yang, Q. Chen, C.W. Niu, Z. Xi, W.C. Yang*, and G.F. Yang* (2020) Fragment-based discovery of flexible inhibitor targeting wild-type acetohydroxyacid synthase and P197L mutant. Pest. Manag. Sci. 76: 3403–3412.