Li-Bo Zhang PhD

Libo Zhang

Professor of Biochemistry

Doctoral Supervisor

State Key Laboratory of Green Pesticides

Contact details

227 Physics and Chemistry Building, East Campus, Guizhou University

Email: lbzhang@gzu.edu.cn

Phone :13765005126

Qualifications

BSc – Henan Normal University, China 2007

MSc – Jilin University, China 2009

PhD – University of South Carolina, USA 2020

Positions held

2009-2011 Research AssistantNational Institute of Biological Sciences, Beijing, China

2011-2015 Research Associate Novo Nordisk Research Center China, Beijing, China   

2020-2023 Postdoc  University of California (Davis), USA

2023 – present Professor Guizhou University, China

Profile

Libo Zhang’s research focuses on the design and synthesis of oligosaccharides, peptides, and their assemblies for green pesticide discovery using principles and methods of enzymatic engineering, protein and material assembly, and synthetic biology. In 2022, he was supported by the National High-Level Youth Talents Overseas Excellent Young Program. He has served on editorial board of Journal of Plant Protection and review editor of Frontiers in Chemical Biology since 2023. He has published over 30 research papers in journals such as Carbohydr. Polym, JACS, Bioresour. Technol., JACS Au, Mater. Sci. Eng. C，ACS Sustain. Chem. Eng.

Selected recent publications (*Corresponding author)

 1.Muhammad Rahil Afzal, Misbah Naz, Youbo Yu, Lisha Yan, Peiyi Wang, Janaki Mohotti, GeFei Hao, Jing-Jiang Zhou, Zhuo Chen, Libo Zhang*, Qian Wang. Root exudates: The rhizospheric frontier for advancing sustainable plant protection. Resour. Environ. Sustain. 2025, 21, 100249.

2.Xiaoxue Tian, Hongsheng Hu, Lijun Fan, Jinghan Yang, Haicong Zhao, Libo Zhang*, Dekun Hu, Gefei Hao, Fengpei Du, Peiyi Wang.* Smart β-cyclodextrin-dominated helical supramolecular dendritic assemblies improve the foliar affinity and biofilm disruption for treating alarming bacterial diseases, Carbohydrate Polymers, 2025, 348, part A, 122823.  

3.Libo Zhang*, Dumei Ma, Youbo Yu, Wiewei Luo, Shilong Jiang, Sheng Feng, Zhuo Chen. Advances in biomacromolecule-functionalized magnetic particles for phytopathogen detection, Talanta, 2025, 281, 126876.

4.Arin Gucchait, Jingxin Fu, Libo Zhang, Anand Kumar Agrahari, Zimin Zheng, Xiaohong Yang, Hai Yu, Xiaoxiao Yang, Ajit Varki, Xi Chen. Advancing chemoenzymatic synthesis and covalent immobilization of a comprehensive ganglio-glycosphingolipid library enables functional multiplex bead assays. Journal of the American Chemical Society,2025, accepted.

5.Yuanyuan Bai, Hai Yu, Libo Zhang, Xiaoxiao Yang, Anand Kumar Agrahari, Zimin Zheng, William Su, Nathan Tang, and Xi Chen. EASyMaps for systematic chemoenzymatic synthesis of human milk oligosaccharides (HMOs) containing a tetraose core. JACS Au, 2025, 5, 822–837.

6.Hai Yu, Zimin Zheng, Libo Zhang, Xiaohong Yang, Ajit Varki, Xi Chen. Chemoenzymatic synthesis of N-Acetyl Analogues of 9-O-Acetylated b-Series Gangliosides. Tetrahedron 2023, 142,133522.

7.Libo Zhang, Yanhong Li, Riyao Li, Xiaohong Yang, Zimin Zheng, Jingxin Fu, Hai Yu, and Xi Chen. Glycoprotein in vitro N-Glycan Processing Using Enzymes Ex-pressed in E. coli. Molecules, 2023, 28(6), 2753

8.Hai Yu, Libo Zhang (co-first), Xiaohong Yang, Yuanyuan Bai, Xi Chen. Process Engineering and Glycosyltransferase Improvement for Short Route Chemoenzymatic Total Synthesis of GM1 Gangliosides. Chemistry–A European Journal, 2023, e202300005

9.Yihua Ren, Libo Zhang (co-first), Tao Sun, Yingwu Yin and Qian Wang. Enzyme Immobilization on Delignified Bamboo Scaffold as Green Hierarchical Bioreactor. ACS Sustainable Chemistry & Engineering, 2022, 10, 19, 6244–6254 (Cover feature)

10.Libo Zhang, Hai Yu, Yuanyuan Bai, Bijoyananda Mishra, Xiaoxiao Yang, Jing Wang, Evan B. Yu, Riyao Li and Xi Chen. A fluorescent magnetic bead-immobilized neoglycoprotein suspension multiplex array for galectin-binding studies. Molecules, 2021, 26(20), 6194

11.Hai Yu, Madhusudhan Reddy Gadi, Yuanyuan Bai, Libo Zhang, Lei Li, Jun Yin, Peng G. Wang and Xi Chen. Chemoenzymatic total synthesis of GM3 gangliosides containing different sialic acid forms and various fatty acyl chains. Journal of Organic Chemistry, 2021, 86(13) 8672-8682

12.Libo Zhang and Qian Wang. Harnessing P450 enzyme for biotechnology and synthetic biology. Chembiochem, 2021, 23 (3), e202100439 (Cover feature)

13.Libo Zhang, Dumei Ma, Yingwu Yin, Qian Wang. Using small molecules to enhance P450 OleT enzyme activity in situ. Chemistry-A European journal, 2021,27(35), 8940-8945 (Cover feature)

14.Dumei Ma, Libo Zhang (co-first), Yingwu Yin, Qian Wang. Spectroscopic studies of the interaction between phosphorus heterocycles and cytochrome P450. Journal of Pharmaceutical Analysis, 2021, 11(6), 757–763

15.Dumei Ma, Libo Zhang (co-first), Yingwu Yin, Qian Wang. Structure-based design, synthesis of novel probes for Cytochrome P450 OleT. Chinese Chemical Letters, 2021, 32 (4), 1466–1469

16.Libo Zhang, Olivia M. Manley, Dumei Ma, Yingwu Yin, Thomas M. Makris, Qian Wang. Enhanced P450 OleTSA catalysis promoted by glucose oxidase-based H2O2 production from abundant sugars. Bioresource technology, 2020, 311, 123538

17.Libo Zhang, Andrew Beatty, Lin Lu, Akrm Abdalrahman, Thomas Makris, Guiren Wang and Qian Wang. Microfluidic-assisted polymer-protein assembly to fabricate homogeneous functional nanoparticles. Materials Science and Engineering C, 2020, 111, 110768