张利博教授简历

2024-05-10 浏览次数： 3142

张利博教授

性别：男

职称/职务：教授

学位：博士

Email：lbzhang@gzu.edu.cn

个人简介

张利博，教授，博士生导师，国家级青年人才。2020年博士毕业于美国南卡莱罗纳大学，2020年至2023年在加州大学戴维斯分校从事博士后研究。2022年入选国家海外高层次青年人才项目。专注于功能蛋白与高分子等材料共组装，蛋白与小分子相互作用，病原菌相关寡糖及衍生物的化学酶学合成等研究，已在 Carbohydr. Polym, JACS, JACS Au, Bioresour. Technol., Mater. Sci. Eng. C， ACS Sustain. Chem. Eng.,等期刊发表30篇研究论文。本课题组将长期致力于生物大分子在植物保护领域的开发和研究，包括基于寡糖、多肽、蛋白质及其组装体的植物诱抗剂研发及非自然多酶体系再合成生物学中的开发及应用研究。

工作经历

贵州大学精细化工研究开发中心 — 08/2023至今教授/博士生导师

加州大学戴维斯分校,戴维斯美国 — 07/2020–07/2023 博士后研究员合作导师：陈希

诺和诺德研发中心,北京中国 — 08/2011–08/2015 助理研究员

北京生命科学研究所,北京中国 — 09/2009–06/2011 研究助理

教育经历

博士南卡莱罗纳大学 — 08/2015–08/2020 导师:王倩

硕士吉林大学 — 09/2007–06/2009 导师:刘松财,艾永兴

学士河南师范大学,生物科学 — 09/2003–06/2007

代表性成果

1.Muhammad Rahil Afzal, Misbah Naz, Youbo Yu, Lisha Yan, Peiyi Wang, Janaki Mohotti, GeFei Hao, Jing-Jiang Zhou, Zhuo Chen, Libo Zhang*, Qian Wang. Root exudates: The rhizospheric frontier for advancing sustainable plant protection. Resour. Environ. Sustain. 2025, 21, 100249.

2.Xiaoxue Tian, Hongsheng Hu, Lijun Fan, Jinghan Yang, Haicong Zhao, Libo Zhang*, Dekun Hu , Gefei Hao, Fengpei Du, Peiyi Wang* Smart β-cyclodextrin-dominated helical supramolecular dendritic assemblies improve the foliar affinity and biofilm disruption for treating alarming bacterial diseases, Carbohydrate Polymers, 2025, 348, part A, 122823.

3.Libo Zhang*, Dumei Ma, Youbo Yu, Wiewei Luo, Shilong Jiang, Sheng Feng, Zhuo Chen* Advances in biomacromolecule-functionalized magnetic particles for phytopathogen detection, Talanta, 2025, 281, 126876.

4.Arin Gucchait, Jingxin Fu, Libo Zhang, Anand Kumar Agrahari, Zimin Zheng, Xiaohong Yang, Hai Yu, Xiaoxiao Yang, Ajit Varki, Xi Chen* Advancing chemoenzymatic synthesis and covalent immobilization of a comprehensive ganglio-glycosphingolipid library enables functional multiplex bead assays. Journal of the American Chemical Society,2025, accepted.

5.Yuanyuan Bai, Hai Yu, Libo Zhang, Xiaoxiao Yang, Anand Kumar Agrahari, Zimin Zheng, William Su, Nathan Tang, and Xi Chen. EASyMaps for systematic chemoenzymatic synthesis of human milk oligosaccharides (HMOs) containing a tetraose core. JACS Au, 2025, 5, 822–837.

6.Libo Zhang, Yanhong Li, Riyao Li, Xiaohong Yang, Zimin Zheng, Jingxin Fu, Hai Yu, and Xi Chen. Glycoprotein in vitro N-Glycan Processing Using Enzymes Ex-pressed in E. coli. Molecules, 2023, 28(6), 2753

7.Hai Yu, Libo Zhang (co-first), Xiaohong Yang, Yuanyuan Bai, Xi Chen. Process Engineering and Glycosyltransferase Improvement for Short Route Chemoenzymatic Total Synthesis of GM1 Gangliosides. Chemistry–A European Journal, 2023, e202300005

8.Yihua Ren, Libo Zhang (co-first), Tao Sun, Yingwu Yin and Qian Wang. Enzyme Immobilization on Delignified Bamboo Scaffold as Green Hierarchical Bioreactor. ACS Sustainable Chemistry & Engineering, 2022, 10, 19, 6244–6254 (Cover feature)

9.Libo Zhang, Hai Yu, Yuanyuan Bai, Bijoyananda Mishra, Xiaoxiao Yang, Jing Wang, Evan B. Yu, Riyao Li and Xi Chen. A fluorescent magnetic bead-immobilized neoglycoprotein suspension multiplex array for galectin-binding studies. Molecules, 2021, 26(20), 6194

10.Libo Zhang and Qian Wang. Harnessing P450 enzyme for biotechnology and synthetic biology. Chembiochem, 2021, 23 (3), e202100439 (Cover feature)

11.Libo Zhang, Dumei Ma, Yingwu Yin, Qian Wang. Using small molecules to enhance P450 OleT enzyme activity in situ. Chemistry-A European journal, 2021,27(35), 8940-8945 (Cover feature)

12.Dumei Ma, Libo Zhang (co-first), Yingwu Yin, Qian Wang. Spectroscopic studies of the interaction between phosphorus heterocycles and cytochrome P450. Journal of Pharmaceutical Analysis, 2021, 11(6), 757–763

13.Dumei Ma, Libo Zhang (co-first), Yingwu Yin, Qian Wang. Structure-based design, synthesis of novel probes for Cytochrome P450 OleT. Chinese Chemical Letters, 2021, 32 (4), 1466–1469

14.Libo Zhang, Olivia M. Manley, Dumei Ma, Yingwu Yin, Thomas M. Makris, Qian Wang. Enhanced P450 OleTSA catalysis promoted by glucose oxidase-based H2O2 production from abundant sugars. Bioresource technology, 2020, 311, 123538

15.Libo Zhang, Andrew Beatty, Lin Lu, Akrm Abdalrahman, Thomas Makris, Guiren Wang and Qian Wang. Microfluidic-assisted polymer-protein assembly to fabricate homogeneous functional nanoparticles. Materials Science and Engineering C, 2020, 111, 110768