张利博教授

个人简介

张利博，教授，博士生导师，国家级青年人才。2020年博士毕业于美国南卡罗来纳大学，2020年至2023年在加州大学戴维斯分校从事博士后研究。2022年入选国家海外高层次青年人才项目。在 Green Chem., J. Nanobiotechnology，Chem. Eng. J., Trends Plant Sci., Carbohydr. Polym.等期刊发表40余篇研究论文，致力于生物大分子在植物保护领域的开发和研究。

工作经历

教育经历

学术兼职

教学工作

本科生课程：

1. 分子生物学

2. 植物生物防治

研究生课程：

Pesticide Science / New Progress in Pesticide Research

  研究方向

1. 非自然多酶体系在合成生物学中的开发及应用

2. 高效植物免疫诱抗剂的开发与机制研究

3. 基于生物大分子的绿色农药及农药递送体系

代表性科研项目

1. 优秀青年科学基金海外项目

2. 贵州大学科技咨询专家科研启动项目：植物化学保护

3. 贵州省高层次人才培养支持工程科技创新领域领军人才

代表性专著及论文

1. Xingcheng Zhou, Jie Hong, Li Yang, Satyabrata Nanda, Youbo Yu, You Wang, Krongthong Kamonsuangkasem, Ming Chang, Janaki Mohotti, Gefei Hao, Peiyi Wang*, Libo Zhang*. Metal-driven nanoassembly of hexahistidine-tagged melittin enables superior phytopathogen biofilm degradation with attenuated toxicity. Journal of Nanobiotechnology, doi.org/10.1186/s12951-026-04732-4.

2. Darshika Sandamini Polwatte Koralalage, Qi Wang, Janaki Mohotti , Libo Zhang*, Chengyun Li*, Ming Chang*. Jasmonate before salicylate in systemic acquired resistance. Trends in Plant Science, 2026, 31, 8, 983.

3. Youbo Yu, Jin Huangb, Wei Wang, Lisha Yana, Liping Zhana, Janaki Mohottic, Pan Tan*, Gefei Hao*, Libo Zhang*. AI-Guided Discovery of an Efficient Chitinase Enables Green Production of Chitobioses with Distinct Cadmium Stress-Alleviating Efficacy in Rice. Chemical Engineering Journal, 2026, 536,175906.

4. Yixuan Yang, Junqi Hou, Yuanli Wang, Libo Zhang*, Jinyu He*, Ming Chang*. PBS1 in heat-immunity crosstalk. Journal of Integrative Plant Biology (2026, doi.org/10.1111/jipb.70190)

5. Youbo Yu, Xingcheng Zhou, Lisha Yan, Li Yang, Jie Hong*, Krongthong Kamonsuangkasem, Peiyi Wang, WMWW Kandegama, Gefei Hao, Libo Zhang*. Spatial organization of an enzyme cascade in Ni-ZIF-8 framework for efficient sugar nucleotide synthesis. Green Chemistry, 2026, 28, 4474-4489. (Cover feature)

6. Arin Gucchait, Jingxin Fu, Libo Zhang, Anand Kumar Agrahari, Zimin Zheng, Xiaohong Yang, Hai Yu, Xiaoxiao Yang, Ajit Varki, Xi Chen. Advancing Chemoenzymatic Synthesis and Covalent Immobilization of a Comprehensive Ganglio-glycosphingolipid Library Enables Functional Multiplex Bead Assays. Journal of the American Chemical Society, 2025, 147, 40, 36717.

7. Muhammad Rahil Afzal, Misbah Naz, Youbo Yu, Lisha Yan, Peiyi Wang, Janaki Mohotti, GeFei Hao, Jing-Jiang Zhou, Zhuo Chen, Libo Zhang*, Qian Wang. Root exudates: The rhizospheric frontier for advancing sustainable plant protection. Resources, Environment and Sustainability,2025, 21, 100249.

8. Xiaoxue Tian, Hongsheng Hu, Lijun Fan, Jinghan Yang, Haicong Zhao, Libo Zhang*, Dekun Hu, Gefei Hao, Fengpei Du, Peiyi Wang.* Smart β-cyclodextrin-dominated helical supramolecular dendritic assemblies improve the foliar affinity and biofilm disruption for treating alarming bacterial diseases, Carbohydrate Polymers, 2025, 348, part A, 122823.

9. Libo Zhang*, Dumei Ma, Youbo Yu, Wiewei Luo, Shilong Jiang, Sheng Feng, Zhuo Chen. Advances in biomacromolecule-functionalized magnetic particles for phytopathogen detection, Talanta, 2025, 281, 126876.

10. Yuanyuan Bai, Hai Yu, Libo Zhang, Xiaoxiao Yang, Anand Kumar Agrahari, Zimin Zheng, William Su, Nathan Tang, and Xi Chen. EASyMaps for systematic chemoenzymatic synthesis of human milk oligosaccharides (HMOs) containing a tetraose core. JACS Au, 2025, 5, 822–837.

11. Xiansu Wang, Chengyan Xia, Dongxue Li, Fenghua Liu, Jun Zhang, Wenjing Xie, Dan Cheng, Libo Zhang, Zhuo Chen. Eugenol Potentially Targets Oleate Delta-12 Desaturase of Botrytis cinerea and Controls Gray Mold as Part of a Combination of Multiple Fungicidal Components. Phytopathology, 2025, doi.org/10.1094/PHYTO-06-25-0227-R

12. Shilong Jiang, Lei Hu, Zhibing Rui, Delu Wang, Libo Zhang, Jing-Jiang Zhou, Zhuo Chen. Lasiodiplodia theobromae, a Pathogen of Plants and Humans, Spreading to New Crop Hosts Globally. Journal of Agricultural and Food Chemistry, 2025, 73, 34, 21223

发明专利

1. Libo Zhang; Xiaoxiao Yang; Xi Chen; Yuanyuan Bai; Hai Yu; Functionalized human milk oligosaccharide and methods for producing them, 2023-01-09, WIPO, WO2023141513A2

2. Gucchait Arin; Xi Chen; Hai Yu; Libo Zhang; Glycosyltransferase engineering for chemoenzymatic total synthesis of gangliosides, 2023-11-01, WIPO, WO2024097788A1

代表性国际会议报告

1. Green production of bioactive oligosaccharides via highly efficient enzymatic

tandem catalysis, 第六届国际绿色植保技术创新会议， 科伦坡， 2026-02-18至2026-03-24

2. Bio-manufacturing of chitobioses and their applications for plant protection, General Sir John Kotelawala Defence University 19^th International Research Conference, Colombo, 20^th August - 21^th August, 2026