薛伟教授简历

薛伟教授简历

2025-09-10     

工作经历

2012年12 月——至今                  精细化工研究开发中心       教授

2007年 12 月——2012年12 月      精细化工研究开发中心      副教授

2005年 12 月——2007年12 月      精细化工研究开发中心      讲师

教育经历

2005年9 月——2011年 7 月      贵州大学         博士  

2003年9 月——2005年 7 月       贵州大学        硕士

1988年 9月——1992年 7 月       贵州师范大学   本科

教学工作

本科生课程：

化学与健康（通识选修）

研究生课程：

精细化学品化学

   研究方向

1. 绿色药物设计合成；

2. 天然源新农药创制；

科研项目

  1. 国家自然科学基金(32072446)，查耳酮衍生物设计合成及生物活性研究, 2021.01-2024.12

2. 国家自然科学基金(21867003)，杨梅素衍生物设计、合成及生物活性研究, 2019.01-2022.12

代表性论著

论文：

1. Miaohe Zhang, Shuang Fenga, Junrong Song, Xianghui Ruan,* Wei Xue,* Formononetin derivatives containing benzyl piperidine: a brand new, highly efficient inhibitor targeting Xanthomonas spp. Journal of Advanced Research, 2025,73,133-146.

2. Tianyu Deng, Hui Xin, Xingping Luo, Qing Zhou, Yuhong Wang, Chunmei Hu, Hong Fu, Wei Xue,* Antifungal activity of chalcone derivatives containing 1,2,3,4-tetrahydroquinoline and studies on them as potential SDH inhibitors,Pest Management Science, 2025, 81, 1251-1260.

3. Hui Xin, Yi Liu, Tianyu Deng, Hong Fu, Yuhong Wang, Chunmei Hu, Haotao Pu, Xingping Luo, Wei Xue*, Discovery of potential fungicidal candidates: Chalcone derivatives containing piperidine and thiourea fragments,Journal of Agricultural and Food Chemistry, 2025,73, 17, 10101-10109.

4. Jiao Tian, Yi Liu, Hui Xin, Chunmei Hu, Jieyu Li, Yuhong Wang, Xingping Luo, Yujiao Qiu, Wei Xue, * Discovery of Novel Flavonoid Derivatives Containing Benzothiazole as Potential Antifungal Agents, Pest Management Science, 2025,81,4,2288-2299.

5. Piao Mao, Li Xing, Bangcan He, Tianyu Deng, Yishan Qin, Yuzhi Hu, Youshan An, Wei Xue,*Antiviral activity evaluation and action mechanism of chalcone derivatives containing phenoxypyridine, Molecular Diversity, 2025, 29, 695-709.

6. Bangcan He, Yuzhi Hu, Yishan Qin, Yufang Zhang, Xingping Luo, Zhenchao Wang,* Wei Xue,* Design, synthesis and antiviral activity of indole derivatives containing quinoline moiety, Molecular Diversity, 2025, 29, 1091-1107.

7. Yi Liu, Hui Xin, Yuhong Wang, Qing Zhou, Jiao Tian, Chunmei Hu, Xingping Luo, Haotao Pu, Wei Xue,* Flavonol derivatives containing piperazine and quinoxaline fragments: synthesis and antifungal activity, Molecular Diversity,2025, 29, 2193-2208.

8. Tianyu Deng, Kaini Meng, Youshan An, Hong Fu, Yuhong Wang, Hongqian Zou, Da Liu,* Wei Xue,* Bioactivity ofchalcone derivatives containing 1,2,3,4-tetrahydroquinoline against Xanthomonas citri pv.mangiferae, Pest Management Science, 2025, 81(9), 5813-5826.

9. Miaohe Zhang; Shuang Feng; Junyong Song; Wei Xue, Development and action mechanism of a series of novel antibacterial compounds based on natural product formononetin for controlling crop diseases, Journal of Agricultural and Food Chemistry, 2025, 73, 18680-18690.

10. Youshan An, Kaini Meng, Tianyu Deng, Hong Fu, Hongqian Zou, Yujiao Qiu, Haotao Pu, Yufang Zhang, Mingman Sun, Wei Xue,* Design, synthesis and anti-TMV activity studies of myricetin derivatives containing oxime-ether triazole, Journal of Molecular Structure, 2025, 1348, 143431.

11. Nian Zhang, Wei Zeng, Qing Zhou, Zhiling Sun, Kaini Meng, Yishan Qin, Yuzhi Hu, Wei Xue,* Design, synthesis and bioactivity of chalcone derivatives containing benzoxazole,Arabian Journal of Chemistry, 2024, 17, 105368.

12. Chunmei Yuan, Tao Zhang, Jiao Tian, Tianyu Deng, Hui Xin, Yi Liu, Yufang Zhang, Wei Xue,* A potential antifungal agent: insight into the antifungal mechanism a gainst Phomopsis sp, Arabian Journal of Chemistry, 2024, 17, 105480.

13. Piao Mao, Tianyu Deng, Jiao Tian, Yi Liu, Hui Xin, Youshan An, Yuzhi Hu, Yishan Qin, Wei Xue,* Design, synthesis, and antifungal activities of chalcone derivatives containing piperidine and sulfonamide moiety, Journal of Saudi Chemical Society，2024, 28, 101791.

14. Chenyu Gong, Yuanxiang Zhou, Qing Zhou, Kaini Meng, Zhiling Sun, Wei Zeng, Youshan An, Yishan Qin, Xingping Luo, Wei Xue,* Novel flavonoid derivatives containing 1,2,4-triazolo[4,3-a]pyridine as potential antifungal agents: design, synthesis, and biological evaluation, Journal of Saudi Chemical Society, 2024, 28, 101797.

15. Yuanxiang Zhou, Zhiling Sun, Qing Zhou, Wei Zeng, Miaohe Zhang, Shuang Feng, Wei Xue,* Novel flavonol derivatives containing benzoxazole as potential antiviral agents: design, synthesis, and biological evaluation, Molecular Diversity, 2024,28,3919-3935.

16. Bangcan He,Yuzhi Hu, Piao Mao, Tianyu Deng, Yuhong Wang, Xingping Luo, Hongqian Zou, Zhenchao Wang, Wei Xue,*Design, Synthesis and Antifungal Activity of Indole Derivatives Containing 1,3,4-oxadiazole, Arabian Journal of Chemistry, 2024,17, 105758.

17. Bangcan He, Yuzhi Hu, Li Xing, Yishan Qing, Kaini Meng, Wei Zeng, Zhiling Shun, Zhenchao Wang,* Wei Xue,* Antibacterial and antiviral activities of indole derivatives containing 1,3,4-thiadiazole, Journal of Agricultural and Food Chemistry, 2024, 72, 18, 10227-10235.

18. Zhiling Sun, Wei Zeng, Qing Zhou, Yujiao Qiu, Yuzhi Hu, Hong Fu, Hongqian Zou, Yuhong Wang, Chunmei Hu, Jieyu Li, Wei Xue, Design, synthesis and antiviral activity of flavonol derivatives containing piperidine sulfonamide,Arabian Journal of Chemistry, 2024, 17, 105944.

19. Yi Liu, Jiao Tian, Wei Zeng, Yuhong Wang, Chunmei Hu, Xingping Luo, Yujiao Qiu, Haotao Pu, Yongjun Wu, Wei Xue*, Antifungal activity of novel flavonol derivatives containing quinoxaline, Journal of Agricultural and Food Chemistry, 2024, 72, 43, 23766-23775.

20. Wei Zeng, Zhiling Sun, Yi Liu, Qing Zhou, Yufang Zhang, Yujiao Qiu, Hong Fu, Hongqian Zou, Haotao Pu, Wei Xue*Design and research of new virulence factor inhibitors for plant bacterial disease control, Arabian Journal of Chemistry, 2024, 17(12), 106042.

21. Youshan An, Hongqian Zou, Qing Zhou, Tianyu Deng, Jiao Tian, Yujiao Qiu, Wei Xue, Design, synthesis and biological activity studies of myricetin derivatives containing diisopropanolamine structure" Journal of Agricultural and Food Chemistry, 2024, 72, 25034-25044.

22. Kaini Meng, Tianyu Deng, Min Liub, Haotao Pu, Yufang Zhang, Hongqian Zou, Yunping Xing, Wei Xue*，Novel flavonoid derivatives containing 1,2,4-triazole Schiff bases as potential antifungal agents: design, synthesis, and biological evaluation,Bioorganic Chemistry, 2024, 153, 107965.

23. Shuang Feng, Miaohe Zhang, Junrong Song, Xianghui Ruan, Xue, Wei, Discovery of Highly Effective Antibacterial Agents based on Chalcone Scaffold against Plant Pathogens, Journal of Agricultural and Food Chemistry,2024, 72, 27808-27817.

24. Wenliang Zhan, Ran Zhou, Piao Mao, Chunmei Yuan, Tao Zhang, Yi Liu, Jiao Tian, Hua Wang*, Wei Xue,* Synthesis, antifungal activity and mechanism of Action of novel chalcone derivatives containing 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole, Molecular Diversity, 2024, 28, 461-474.

25. Qifan Wang, Li Xing, Yuanquan Zhang, Chenyu Gong, Yuanxiang Zhou, Nian Zhang, Bangchan He and Wei Xue*, Antiviral activity evaluation and action mechanism of myricetin derivatives containing thioether quinoline moiety, Molecular Diversity, 2024, 28, 1039-1055.

授权发明专利

1. Wei Xue, Shichun, Jiang, Ziyou Huai, Xu Tang, Yinjiu Huang, Liwei Liu, Mei Chen, Jun He, Shijun Su, 4-(N-methyl) aminopiperidine myricetin derivative containing dithiocarbamate, preparation method and application, PCT/CN2019/123150, Patent No.: US 12,043,617 B2 申请日2019年12月 29日，授权日2024年7月23日

2. Wei Xue, Shichun Jiang, Ying Chen, Shijun Su, Jun He, Mei Chen, Meimei Jin, Ming He, Jun Wang, Sulfonamide-containing 4-(N-methyl) aminopiperidine myricetin derivatives, preparation method and application, PCT/CN2019/124090, Patent No.: US 12,063,930 B2申请日2019年12月 26日，授权日2024年8月20日

3. 薛伟，孙楠，潘思竹，龚晨裕，周远香，邓天宇，安有山，孟开妮，卢平，含噻唑肟醚的查耳酮类化合物及其制备方法和应用，中国发明专利：ZL 202310074830.8，申请日：2023 年 02 月 07 日，授权日2024年5月24日

4. 薛伟，陈帅，潘思竹，曾微，田姣，刘燚，孙治灵，卢平，含哒嗪的查耳酮衍生物及其制备方法和应用，中国发明专利：ZL 202310072400.2，申请日2023年2月7日,授权日2024年9月3日

5. 薛伟，胡蝶，潘思竹，孙楠，张念，周远香，曾微，辛惠，一种含吲哚结构的查耳酮衍生物，其制备方法及应用, 中国发明专利：ZL 202310150947X, 申请日：2023 年 02 月 22 日,授权日2024年10月18日

6. 薛伟，王启帆，潘思竹，张源泉，幸丽，周远香，龚晨裕，何帮灿，张念，卢平，一类含1,2,4-三唑并[3,4-b]-1,3,4-噻二唑杨梅素化合物及其制备方法，中国发明专利：ZL 202211455216.8，申请日2022年11月21日，授权日2024年11月5日